Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death
نویسندگان
چکیده
منابع مشابه
Habitat destruction: death by a thousand cuts
Humankind has dramatically transformed much of the Earth’s surface and its natural ecosystems. This process is not new—it has been ongoing for millennia—but it has accelerated sharply over the last two centuries, and especially in the last several decades. Today, the loss and degradation of natural habitats can be likened to a war of attrition. Many natural ecosystems are being progressively ra...
متن کاملNeurodegeneration and microtubule dynamics: death by a thousand cuts
Microtubules form important cytoskeletal structures that play a role in establishing and maintaining neuronal polarity, regulating neuronal morphology, transporting cargo, and scaffolding signaling molecules to form signaling hubs. Within a neuronal cell, microtubules are found to have variable lengths and can be both stable and dynamic. Microtubule associated proteins, post-translational modif...
متن کاملCorrigendum: Neurodegeneration and microtubule dynamics: death by a thousand cuts
[This corrects the article on p. 343 in vol. 9, PMID: 26441521.].
متن کاملProtease activation during apoptosis: Death by a thousand cuts?
The concept that cell death can be a regulated process under molecular control is now well established. Much evidence also indicates that the molecular machinery for death has been well conserved through evolution. Until recently, efforts to identify components of this machinery were focused primarily on identifying endonucleases capable of cleaving DNA at internucleosomal sites, since this typ...
متن کاملCell death induced by granzyme C.
Although the functions of granzymes A and B have been defined, the functions of the other highly expressed granzymes (Gzms) of murine cytotoxic lymphocytes (C, D, and F) have not yet been evaluated. In this report, we describe the ability of murine GzmC (which is most closely related to human granzyme H) to cause cell death. The induction of death requires its protease activity and is character...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annual Review of Immunology
سال: 2008
ISSN: 0732-0582,1545-3278
DOI: 10.1146/annurev.immunol.26.021607.090404